General Information

  • ID:  hor004406
  • Uniprot ID:  P30250
  • Protein name:  Locustatachykinin-4
  • Gene name:  NA
  • Organism:  Locusta migratoria (Migratory locust)
  • Family:  Tachykinin family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Locusta (genus), Oedipodinae (subfamily), Acrididae (family), Acridoidea (superfamily), Acridomorpha, Acrididea (infraorder), Caelifera (suborder), Orthoptera (order), Polyneoptera (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  APSLGFHGVR
  • Length:  10
  • Propeptide:  APSLGFHGVR
  • Signal peptide:  NA
  • Modification:  T10 Arginine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Myoactive peptide. Stimulates the contraction of the oviduct and foregut.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor004406_AF2.pdbhor004406_ESM.pdb

Physical Information

Mass: 120090 Formula: C47H73N15O12
Absent amino acids: CDEIKMNQTWY Common amino acids: G
pI: 10.55 Basic residues: 2
Polar residues: 3 Hydrophobic residues: 4
Hydrophobicity: 17 Boman Index: -735
Half-Life: 4.4 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 78
Instability Index: 3715 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  2132575
  • Title:  Locustatachykinin III and IV: Two Additional Insect Neuropeptides With Homology to Peptides of the Vertebrate Tachykinin Family